Professor of Health Toxicology

Department of Health Toxicology

* yanhong@mails.tjmu..edu.cn

Academic Areas

Neurotoxicology, Molecular Toxicology

Research Interests

Chronic exposure to food pollutants (specially acrylamide, pesticide residues) and their neurotoxicity.

Food pollutants and their relations to impaired glucose tolerance and lipid metabolism disorders

Selected Professional Affiliations

2005-   Commissioner, Biochemistry and Molecular Toxicology Council, Chinese Toxicology Society

2012     Commissioner, Neurotoxicology Council, Chinese Toxicology Society

2014     Executive member, Hubei Toxicology Council

Courses Taught

Health Toxicology / Clinical Toxicology / Progress in Toxicology

Education

1995-1998         Ph.D., Department of Environmental Toxicology, Tongji Medical College, Wuhan, China,

1992-1995         M.S., Department of Environmental Toxicology, Tongji Medical College, Wuhan, China,

1987-1992         B.S., Tongji Medical College, Wuhan, China

Professional/working Experience

2017-present    Professor, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

2000-2017       Associate Professor, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

1998-2000       Lecturer, Department of Health Toxicology, School of Public Health, Tongji Medical College, Wuhan, China

Past and ongoing projects, funding, programs

2013-2017        The crosstalk between Nrf2 and NF-κB mediated the dopaminergic neuron degeneration induced by Acrylamide, NSFC, PI

2007-2008       Melatonin attenuates Acrylamide-induced neuronal oxidative stress by activation of Nrf2/HO-1 Signal pathway, NSFC, PI

2013-2014        N-acetylcysteine attenuates Acrylamide- induced apoptosis in stratum in rats. Wuhan Science and Technology Project, PI

Select Publications

Journal Article

* Corresponding author

1.         Dandan Yan, Jianling Yao,Y ing Liu, Xing Zhang, Yiqi Wang, Xiaoyi Chen, Liegang Liu, Nian Shi, Hong Yan*. Tau hyperphosphorylation and P-CREB reduction are involved in acrylamide-induced spatial memory impairment: Suppression by curcumin.  Brain, Behavior, and Immunity. 2018, 71: 66-80

2.        Xiaoqi Pan, Xu Wu, Dandan Yan, Cheng Peng, Chaolong Rao, Hong Yan*. Acrylamide-induced oxidative stress and inflammatory response are alleviated by N-acetylcysteine in PC12 cells: Involvement of the crosstalk between Nrf2 and NF-κB pathways regulated by MAPKs. Toxicology Letters.2018,288：55-64

3.        Dandan Yan, Yunjian Zhang, Liegang Liu, Nian Shi, Hong Yan*. Pesticide exposure and risk of Parkinson's disease: Dose-response meta-analysis of observational studies. Regulatory Toxicology and Pharmacology. 2018, 96:57-63

4.        Dandan Yan, Xiaoqi Pan,Jianling Yao, Dun Wang, Xu Wu, Xiaoyi Chen, Nian Shi, Hong Yan*. MAPKs and NF-κB mediated acrylamide-induced neuropathy in rat striatum and human neuroblastoma cells SY5. Journal of Cellular Biochemistry. 2018, DOI:10.1002/jcb.27671

5.        Xiaoqi Pan, Dandan Yan, Dun Wang, Xu Wu, Wanyun Zhao, Qing Lu, Hong Yan*. Mitochondrion-mediated apoptosis induced by Acrylamide is regulated by a balance between Nrf2 antioxidant and MAPK signaling pathways in PC12 Cells.  Molecular Neurobiology. 2017; 54(6):4781-4794

6.        Dandan Yan, Yunjian Zhang, Liegang Liu, Hong Yan*. Pesticide exposure and risk of Alzheimer’s disease: a systematic review and meta-analysis. Scientific Reports .2016, Sep 1; 6:32222 | DOI: 10.1038/srep32222

7.        Xiaoqi Pan, Lanlan Zhu, Huiping Lu, Dun Wang, Qing Lu, Hong Yan*. Melatonin attenuates oxidative damage induced by Acrylamide in vitro and in Vivo. Oxidative Medicine and Cellular Longevity .2015;2015:703709. DOI:10.1155/2015/703709

8.       Xiaoqi Pan, XiongxiongGuo, FeiXiong, Guihong Cheng, Qing Lu*, Hong Yan* . Acrylamide increases dopamine levels by affecting dopamine transport and metabolism related genes in the striatal dopaminergic system. Toxicology Letters.2015, 236:60-68,  

9.        .Miao Yu, Di Wang , Wei Yang, Mengjing Xu, Yang Liu ,Siyuan Xu,, Ping Yao，Hong Yan*, Liegang Liu*. Mechanisms of Nrf2/HO-1 pathway up-regulation induced by pu-erh black tea extract supplementation for quinocetone-treated Sprague-Dawley rats. Journal of functional foods. 2015：14:767-778,

10.    Wei Yang, Miao Yu, Juan Fu, Wei Bao, Di Wang, Liping Hao, Ping Yao, Andreas K. Nüssler, Hong Yan*.Liegang Liu*. Deoxynivalenol induced oxidative stress and genotoxicity in human peripheral blood lymphocytes. Food and Chemical Toxicology. 2014,64: 383–396.