Professor of Occupational and Environmental Health
Department of Occupational and Environmental Health
* xue.zhou@hust.edu.cn
Academic Areas
Molecular Toxicology and Carcinogenesis
Research Interests
Epigenetic mechanisms of heavy metal carcinogenesis
Toxicity and molecular mechanisms of nanomaterials
Selected Professional Affiliations
2014 Committee, Youth Council, Environmental Health Division, Chinese Preventive Medicine Association
2016 Executive Committee and Secretary, Environmental Health Council, Preventive Medicine Association of Hubei Province
2018 Committee, Mutagenesis Council, Chinese Environmental Mutagen Society
Courses Taught
Environmental Hygiene / Preventive Medicine / Advances in Preventive Medicine / New Techniques in Environment and Health
Education
2004-2010 Ph.D., Department of Environmental Medicine, New York University, New York, U.S.A.
1999-2003 B.S., Department of Environmental Science, Wuhan University, Wuhan, China
Professional/working Experience
2010-2018 Associate Professor, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
2018-present Professor, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Past and ongoing projects, funding, programs
2020-2023 Exosomal circ-SHPRH: role and mechanism of action in cadmium-induced malignant transformation of bronchial epithelial cells, NSFC, PI
2017-2020 SIRT6: its role and mechanism of action in multi-walled carbon nanotubes-induced lung fibrosis, NSFC, PI
2013-2015 The role of H3K4 tri-methylation in arsenite-induced malignant transformation of human bronchial epithelial cells, NSFC, PI
2013-2014 Effects of cadmium on H3K9 di-methylation in human bronchial epithelial cells and the mechanism, Hubei Health Department, PI
2012-2014 The role of JARID1 in arsenite-induced H3K4 tri-methylation, the Specialized Research Fund for the Doctoral Program of Higher Education, PI
Select Publications
Books, Patents
1. Modern Environmental Hygiene, 3rd edition, People’s Medical Publishing House, 2019
2. Toxicology, 2nd edition, People’s Medical Publishing House, 2017
3. Experimental Courses for Master’s Students, Medical Section, Huazhong University of Science & Technology Press, 2017
Journal Article
1. Chen P, Tian K, Tu W, Zhang Q, Han L, Zhou X.* Sirtuin 6 inhibits MWCNTs-induced epithelial-mesenchymal transition in human bronchial epithelial cells via inactivating TGF-β1/Smad2 signaling pathway. Toxicology and Applied Pharmacology. 2019;374:1-10.
2. Zhang Q, Tu W, Tian K, Han L, Wang Q, Chen P, Zhou X.* Sirtuin 6 inhibits myofibroblast differentiation via inactivating transforming growth factor-β1/Smad2 and nuclear factor-κB signaling pathways in human fetal lung fibroblasts. Journal of Cellular Biochemistry. 2019;120(1):93-104.
3. Tu W, Zhang Q, Liu Y, Han L, Wang Q, Chen P, Zhang S, Wang A, Zhou X.* Fluoride induces apoptosis via inhibiting SIRT1 activity to activate mitochondrial p53 pathway in human neuroblastoma SH-SY5Y cells. Toxicology and Applied Pharmacology. 2018;347:60-69.
4. Tu W, Liu Y, Xie C, Zhou X.* Arsenite downregulates H3K4 trimethylation and H3K9 dimethylation during transformation of human bronchial epithelial cells. Journal of Applied Toxicology. 2018;38(4):480-488.
5. Xiao C, Liu Y, Xie C, Tu W, Xia Y, Costa M, Zhou X.* Cadmium induces histone H3 lysine methylation by inhibiting histone demethylase activity. Toxicological Sciences. 2015;145(1):80-89.
6. Liu Y, Deng H, Xiao C, Xie C, Zhou X.* Cytotoxicity of calcium rectorite micro/nanoparticles before and after organic modification. Chemical Research in Toxicology. 2014;27(8):1401-1410.
7. Xin S, Li X, Ma Z, Lei Z, Zhao J, Pan S, Zhou X,* Deng H.* Cytotoxicity and antibacterial ability of scaffolds immobilized by polysaccharide/layered silicate composite. Carbohydrate Polymers. 2013;92(2):1880-1886.
8. Xin S, Li X, Zhu Y, Zhang T, Lei Z, Li W, Zhou X,* Deng H.* Nanofibrous mats coated by homocharged biopolymer-layered silicate nanoparticles and their antitumor activity. Colloids and Surfaces B:Biointerfaces. 2013;105:137-143.
9. Deng H, Lin P, Xin S, Huang R, Li W, Du Y, Zhou X,* Yang J.* Quaternized chitosan-layered silicate intercalated composites based nanofibrous mats and their antibacterial activity. Carbohydrate Polymers. 2012;89(2):307-313.
10. Zhou X, Sun H, Chen H, Zavadil J, Kluz T, Arita A, Costa M.* Hypoxia induces trimethylated H3 lysine 4 by inhibition of JARID1A demethylase. Cancer Research. 2010;70(10):4214-4221.
