Tangchun Wu

【Source: | Date:2019-08-05 】


Professor of Occupational and Environmental Health

Department of Occupational and Environmental Health

* wut@mails.tjmu.edu.cn

Academic Areas

Occupational and Environmental Health / Chronic Disease Epidemiology / Molecular Epidemiology

Research Interests

Study of the mechanism and prevention of fine particulate matter-related cardiopulmonary damage/diseases

Genomic, epigenomic and metabolomic profile, and their interactions with environmental pollutants on cardiovascular disease, diabetes and cancer

Carcinogenesis and biomarkers of occupational and environmental related lung cancer and coronary heart diseases

Occupational, environmental exposures and chronic diseases in cohorts

Selected Professional Affiliations

2018-                 Vice Chair, Chinese Medical Doctor Association

2015-2016        President, Cell Stress Society International

2014-                 Vice Director, Chinese Preventive Medicine Association

2005-                Deputy Editor-in-Chief, Chinese Journal of Industrial Hygiene and Occupational Diseases

2003-                Director, Key Lab of Environment and Health, Ministry of Education

Courses Taught

Occupational Health and Occupational Medicine / Paper Writing in English and Chinese

Awards and Honors

2014     National Science & Technology Progress Award (second class), State Council of the People's Republic of China

2013     National Natural Science Award (second class), State Council of the People's Republic of China

2009     Distinguished professor of Changjiang Scholars, chief scientist of national 973 project, ministry of education


1988-1993        Ph.D., School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

1983-1988        B.S., School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Professional/working Experience

2022-present   Dean of Tongji Medical College, Huazhong University of Science & Technology

2015-present    Vice Dean of Tongji Medical College, Huazhong University of Science & Technology

2006-present   Professor, Dean of School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

2001-2006       Professor, Associate Dean, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

1995-2001        Associate Professor and Professor, Institute of Occupational Medicine, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

1995-1996         Post-doctoral fellowship and exchange scientist, Lab. of Molecular and Development Genetics (Prof R.M. Tanguay), Research Center in Health and Life Sciences (RSVS), Pavillon Marchand, Laval University, Ste-Foy, Qc, Canada

Past and ongoing projects, funding, programs

(Listed are projects in recent 5 years)

2019-2021        Atmospheric fine particulate matter and cardiopulmonary diseases in the populations: associations and underlying mechanisms, NSFC

2016-2020       Prospective cohort of common chronic non-communicable diseases in Huazhong region, Ministry of Science & Technology

2017-2020        The epigenetic characteristics caused by ambient particulate matter and their associations with major cardiovascular diseases, NSFC 


Selected Publications

Books, Patents

1.        Tanguay RM and Wu T. Heat Shock Proteins in Environmental Stresses and Environment-related Diseases. In: Radons J, Muelthoff G (Eds), Heat Shock proteins in biology and medicine. 2006. pp 407-420, Research Signpost.

2.       Guo H, Wu T. Small HSP variants and human diseases P383-397. in Tanguay RM and Hightower LE, The Big Book on Small Heat Shock Proteins. Spring, 2015

Journal Article

*Corresponding author

1.   Hao X,# Cheng S,# Wu D,# Wu T,* Lin X,* Wang C.* Reconstruction of the full transmission dynamics of COVID-19 in Wuhan. Nature. 2020;584:420–424. Doi: 10.1038/s41586-020-2554-8.

2.   Pan A,# Liu L,# Wang C,# Guo H,# Hao X,# Wang Q, Huang J, He N, Yu H, Lin X,* Wei S,* Wu T.* Association of public health interventions with the epidemiology of the COVID-19 outbreak in Wuhan, China. JAMA. 2020;323(19):1915-1923. doi: 10.1001/jama.2020.6130.

3.   Yu K,# Lv J,# Qiu G,# Yu C, Guo Y, Bian Z, Yang L, Chen Y, Wang C, Pan A, Liang L, Hu FB, Chen Z, Li L,* Wu T.* China Kadoorie Biobank Study. Cooking fuels and risk of all-cause and cardiopulmonary mortality in urban China: a prospective cohort study. Lancet Global Health. 2020;8(3):e430-e439. doi: 10.1016/S2214-109X(19)30525-X.

4.   Yu K,# Qiu G,# Chan K,# Lam KH, Kurmi OP, Li L,Wu T.* Association of Solid Fuel Use with Risk of Cardiovascular and All-cause Mortality in Rural China. JAMA. 2018;319(13): 1351-1361

5.   Yuan Y, Xiao Y, Feng W, Zhang X, He M, Hu FB, Pan A,* Wu T.* Plasma Metal Concentrations and Incident Coronary Heart Disease in Chinese Adults: The Dongfeng-Tongji Cohort. Environ Health Perspect. 2017;125(10): 107007

6.   Li J, Zhu X, Yu K, Liang L,Wu T.* Genome-Wide Analysis of DNA Methylation and Acute Coronary Syndrome. Circ Res. 2017; 120(11): 1754-1767

7.    Qiu G, Zheng Y, Wang H, Hu FB, Pan A,Wu T.* Plasma Metabolomics Identified Novel Metabolites Associated with Risk of Type 2 Diabetes in Two Prospective Cohorts of Chinese Adults. Int J Epidemiol. 2016; 45(5): 1507~1516

8.   Zhu X,# Li J,# Deng S, Hu FB, Liang L, Wu T.* Genome-Wide Analysis of DNA Methylation and Cigarette Smoking in a Chinese Population. Environ Health Perspect. 2016; 124(7): 966-973

9.   Feng W,# He X,# Chen M,# Kan H, Wu T.* Urinary Metals and Heart Rate Variability: A Cross-Sectional Study of Urban Adults in Wuhan China. Environ Health Perspect. 2015; 123(3): 217~222

10.  Deng Q,# Huang S,# Zhang X, Wu T.* Plasma microRNA Expression and Micronuclei Frequency in Workers Exposed to Polycyclic Aromatic Hydrocarbons. Environ Health Perspect. 2014; 122(7): 719~725  

11.  He M, Wu C,Xu  J, Guo H, Yang H, Zhang X, Sun J, Yu D, Zhou L, Peng T, He Y, Gao Y, Yuan J, Deng Q, Dai X, Tan A, FengY, Zhang H, Min X, Yang X ,Zhu  J, Zhai K, Chang J, Qin X, Tan W, Hu Y,  Lang M, Tao S, Li Y, Li Y, Feng J, Li D, Kim S , Zhang S, Zhang H, Zheng SL, Gui L, Wang Y, Wei S, Wang F, Fang W, Liang Y, Zhai Y, Chen W, Miao X, Zhou G, Hu FB, LiD, Mo Z, Wu T.* A Genome Wide Association Study of Genetic Loci That Influence Tumour Biomarkers Cancer Antigen 19-9, Carcinoembryonic Antigen and Alpha Fetoprotein and Their Associations with Cancer Risk. Gut. 2014; 63(1): 143~151

12.  Chen W,* Liu Y, Wang H, Hnizdo E, Sun Y, Su L, ZhanX, Weng S, Bochmann Frank, Hearl FJ, Chen J, Wu T.* Long-Term Exposure to Silica Dust and Risk of Total and Cause-Specific Mortality in Chinese Workers: A Cohort Study. PLoS Med. 2012; 9(4): e1001206

13.  Guo H, Bai Y, Xu P, Hu Z, Liu L, Wang F, Jin G, Wang F, Deng Q, Tu Y, Feng M, Lu D, Shen H, Wu T.* Functional Promoter -1271G>C Variant of HSPB1 Predicts Lung Cancer Risk and Survival. J Clin Oncol. 2010; 28(11): 1928-1935

14.  Zhang X, He M, Cheng L, Chen Y, Zhou L, Zeng H, Pockley AG, Hu FB,Wu T.* Elevated Heat Shock Protein 60 Levels Are Associated with Higher Risk of Coronary Heart Disease in Chinese. Circulation. 2008; 118(25): 2687~2693

15.  Zhou L, Zhang X, He M, Cheng L, Chen Y, Hu FB, Wu T.* The Associations between single nucleotide polymorphisms on chromosome 9p21 and risk of coronary heart disease in Chinese Han population. Arterioscler Thromb Vasc Biol. 2008;28(11):2085-2089.

16.  Zhang X, He M, Cheng L, Zhou L, Zeng H, Wang J, Wang F, Chen Y, Zhang L, Hu FB, Wu T.* Joint effects of antibody to heat shock protein 60 and hypertension, diabetes and risk of coronary heart disease in Chinese. Clin Chem. 2008;54:1046-1052.

17.  Yang X, Zheng J, Bai Y, Tian F, Yuan J, Sun J, Liang H, Guo L, Tan H, Chen W, Tanguay RM, Wu T.* Using lymphocytes and plasma Hsp70 as biomarkers for assessing coke oven exposure among steel workers. Environ Health Perspect. 2007;115:1573-77.

18.  Liu AL, Lu WQ, Wang ZZ, Chen WH, Lu WH, Yuan J, Nan PH, Sun JY, Zou YL, Zhou LH, Zhang C and Wu T.* Elevated levels of urinary 8-hydroxy-22- deoxyguanosine, lymphocytes micronucleus and serum glutathione S-transferase in workers exposed to coke oven emissions. Environ Health Perspect. 2006;114(5): 673-677.

19.  Chen Y, Bai Y, Yuan J, Chen W, Sun J, Wang H, Liang H, Gua L, Yang X, Tan H, Su Y, Wei Q, Wu T.* Association of polymorphisms in AhR, CYP1A1, GSTM1 and GSTT1 genes with levels of DNA damage in peripheral blood lymphocytes among coke-oven workers. Cancer Epidemiol Biomarkers Prev. 2006;15(9):1703-1707.

20.  Jin X, Xiao C, Tanguay RM, Yang L, Wang F, Chen M, Fu X, Wang R, Deng J, Deng J, Zheng Y, Wei Q, Wu T.* Correlation of lymphocyte Hsp70 levels with neurological deficits in elder patients with cerebral infarction. Am J Med. 2004;117:406-411

21.  Xiao C, Chen S, Li J, Hai T, Lu Q, Sun E, Wang R, Tanguay RM, Wu T.* Association of HSP70 and genotoxic damage in lymphocytes of workers exposed to coke-oven emission. Cell Stress & Chaperones. 2002;7:396-402. (Cover Page)

22.  Wu T,* Jinxiang Ma, Sheng Chen, Yehuan Sun, Chengfeng Xiao, Yajuan Gao, Ruibo Wang, Jacques Poudrier, Michele Dargis, R. William Currie, and Robert M. Tanguay. Association of plasma antibodies against the inducible Hsp70 with hypertension and harsh working conditions. Cell Stress & Chaperones. 2001;6(4):394–401. (Cover Page)

Article Typos & Corrections

1.    Article information: Elevated Heat Shock Protein 60 Levels Are Associated With Higher Risk of Coronary Heart Disease in Chinese. Circulation 2008, 118:2687-2693. 

       Corrections: The median value of 160.24 ng/mL should be corrected as 128.7 ng/mL in the footnote of Table 3 and Table 5, and the corresponding descriptions in Abstract and Results. Hsp60 was divided into low and high groups according to the median value (128.7 ng/mL) among the controls as mentioned in line 9 on page 2689. 

2.    Article information: The Dose-Response Decrease in Heart Rate Variability: Any Association with the Metabolites of Polycyclic Aromatic Hydrocarbons in Coke Oven Workers? PLoS ONE 10(7): e0133802. https://doi.org/10.1371/journal.pone.0133802

     Corrections: There is an error in the first sentence of the Subject and methods subsection of the Material and Methods section. The correct sentence is: A total of 1,628 coke oven workers were recruited from a coke oven plant in Wuhan (Hubei, China) in 2010 and 1333 were included in this study.

3.    Article information: Circulating folate concentrations and risk of coronary artery disease: a prospective cohort study in Chinese adults and a Mendelian randomization analysis. Am J Clin Nutr 2020;111:635–43.

        Corrections:  Some of the values in Table 4 were incorrect. Many values have changed, but the overall conclusions of the article are unaffected by these changes. The authors apologize for the error and for any confusion it may have caused. The detailed correction can be found at https://academic.oup.com/ajcn/article/111/5/1112/5826230