Professor of Epidemiology and Biostatistics
Department of Epidemiology and Biostatistics
* changjiang815@hust.edu.cn
Academic Areas
Cancer Epidemiology / Cancer Genetics and Genomics
Research Interests
Epidemiological studies to investigate the contribution of environmental factors (lifestyle) and genetic susceptibility to cancer
Genetic and genomic studies to identify genes associated with cancer development and progression
Selected Professional Affiliations
Committee Member of the Society of Cancer Etiology of China Anti-Cancer Association
Council member of Chinese Environmental Mutagen Society
Courses Taught
Epidemiology / Preventive Medicine / Big Data of Biomedicine
Awards and Honors
2019 National Program for Support of Top-notch Young Professionals
2018 Young Elite Scientist Sponsorship Program by CAST
2014 Excellent PhD Graduate of Beijing
Education
2009-2014 Ph.D., Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
2005-2009 B.S., Nankai University, Tianjin, China
Professional/working Experience
2019-present Professor, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
2017-2019 Associate Professor, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
2014-2017 Assistant Professor, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Past and ongoing projects, funding, programs
National Program for Support of Top-notch Young Professionals (2,200,000 RMB). (PI).
Young Elite Scientist Sponsorship Program by CAST (2018QNRC001) (450,000 RMB). (PI).
Study of association between genetic variants affecting protein phosphorylation level and susceptibility to esophageal squamous cell carcinoma. Supported by NSFC, From 2019/01-2022/12 (580,000 RMB). (PI).
Select Publications
Journal Article
1. Chang J#, Zhong R#, Tian J#, Li J#, et al. Exome-wide analyses identify low-frequency variant in CYP26B1 and additional coding variants associated with esophageal squamous cell carcinoma. Nat Genet 50, 338-343 (2018).
2. Chang J#, Tian J#, Zhu Y#, Zhong R#, et al. Exome-wide analysis identifies three low-frequency missense variants associated with pancreatic cancer risk in Chinese populations. Nat Commun 9, 3688 (2018)
3. Yang Y, et al, Chang J*, Miao X*. AWESOME: A database of SNPs that affect protein post-translational modifications. Nucleic Acids Research (2018). (*Corresponding author)
4. Chang J#, Tian J#, Yang Y#, Zhong R#, et al. A rare missense variant in TCF7L2 associates with colorectal cancer risk by interacting with a GWAS-identified regulatory variant in the MYC enhancer. Cancer Res 78(17), 5164-5172 (2018).
5. Chang J#, Tan W#, Ling Z#, Xi R#, Shao M#, Chen M#, et al. Genomic analysis of oesophageal squamous-cell carcinoma identifies alcohol drinking-related mutation signature and genomic alterations. Nat Commun 8, 15290 (2017).
6. Li J, Wang Y, et al, Zhong R* & Chang J*. Breast cancer risk-associated variants at 6q25.1 influence risk of hepatocellular carcinoma in a Chinese population. Carcinogenesis 38, 447-454 (2017). (*Corresponding author)
7. Chang J#, Wei L#, et al. Two novel variants on 13q22.1 are associated with risk of esophageal squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev 24, 1774-80 (2015).
8. Chang J, et al. Risk prediction of esophageal squamous-cell carcinoma with common genetic variants and lifestyle factors in Chinese population. Carcinogenesis 34, 1782-6 (2013).
9. Tan D E#, Foo J N#, Bei J X#, Chang J#, et al. Genome-wide association study of B cell non-Hodgkin lymphoma identifies 3q27 as a susceptibility locus in the Chinese population. Nat Genet 45, 804-7 (2013).
10. Wu C#, Kraft P#, Zhai K#, Chang J#, et al. Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions. Nat Genet 44, 1090-7 (2012).
