Professor of Occupational and Environmental Health

Department of Occupational and Environmental Health

* ghuan5011@hust.edu.cn

Academic Areas

Occupational and Environmental Health / Cancer Epidemiology

Research Interests

Molecular epidemiology studies of genetic susceptibility and gene-environment interactions in lung carcinogenesis.

Biomarkers for early screening and exposure assessment of high risk populations of lung cancer.

Studies on the biological effects of occupational and environmental polycyclic aromatic hydrocarbons (PAHs) exposure and genetic damage of coke oven workers with the techniques of molecular and cellular biology, toxicology, and epidemiology.

Selected Professional Affiliations

2014-    Vice Chair, Youth committee of environmental health branch, Chinese Preventive Medicine Association

2016-    Corresponding editors, China Preventive Medicine Vice Chair,

2019-    Young Committee, Professional committee on cancer etiology, Chinese Anti-cancer Association

Courses Taught

Occupational and Environmental Health / Preventive Medicine

Awards and Honors

2017      National Excellent Youth Science Fund of NSFC

2015      National Youth Top Talent Support Program of National High-level Personnel of Special Support Program

2012     100 National Excellent Doctoral Dissertations in China

2012     New Century Excellent Talents in University of Ministry of Education of China

2012     Excellent New Scholar Award of Huazhong University of Science and Technology

Education

2005.9 2010.6 Ph.D., School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

2000.9-2005.6 Bachelor of Medicine in Preventive Medicine, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Professional/working Experience

2010.7 to 2015.10

Associate Professor, Dept. of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology

2012.11 to 2013.11

Visiting Associate Professor, Division of Environmental Health Sciences, School of Public Health, Yale University

2015.11 to present

Professor, Dept. of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology

Past and ongoing projects, funding, programs

Molecular epidemiology on the air pollution induced early health damage and lung cancer (The National Natural Science Foundation of China, grant no. 81722038, 2018-2020)

The interaction effects of coke-oven emissions with genome-wide variations on the early health damage of the coke-oven workers: a prospective occupational cohort study. (The National Natural Science Foundation of China, grant no. 81773398, 2018-2021)

Select Publications

Books, Patents

1.        Guo H, Wu T. Small HSP Variants and Human Disease (Chapter 16) in The Big Book on Small Heat Shock Proteins. Edited by Robert M. Tanguay and Lawrence E. Hightower. Springer, 2015.

Journal Article

Full list can be found at http://www.researcherid.com/rid/C-5572-2011

*Corresponding author

1.        Bai Y, Wang G, Fu W, Lu Y, Wei W, Chen W, Wu X, Meng H, Feng Y, Liu Y, Li G, Wang S, Wang K, Dai J, Li H, Li M, Huang J, Li Y, Wei S, Yuan J, Yao P, Miao X, He M, Zhang X, Yang H, Wu T, Guo H*. Circulating essential metals and lung cancer: Risk assessment and potential molecular effects. Environ Int. 2019;127:685-693.

2.       Dai J, Wu X, Bai Y, Feng W, Wang S, Chen Z, Fu W, Li G, Chen W, Wang G, Feng Y, Liu Y, Meng H, Zhang X, He M, Wu T, Guo H*. Effect of thallium exposure and its interaction with smoking on lung function decline: A prospective cohort study. Environ Int. 2019;127:181-189.

3.       Chen W, Fu W, Deng Q, Li Y, Wang K, Bai Y, Wu X, Li G, Wang G, Huang J, He M, Zhang X, Wu T, Wei S, Guo H*. Multiple metals exposure and chromosome damage: Exploring the mediation effects of microRNAs and their potentials in lung carcinogenesis. Environ Int. 2019;122:291-300.

4.       Fu W, Chen Z, Bai Y, Wu X, Li G, Chen W, Wang G, Wang S, Li X, He M, Zhang X, Wu T, Guo H*. The interaction effects of polycyclic aromatic hydrocarbons exposure and TERT- CLPTM1L variants on longitudinal telomere length shortening: A prospective cohort study. Environ Pollut. 2018;242(Pt B):2100-2110.

5.       Bai Y, Feng W, Wang S, Zhang X, Zhang W, He M, Zhang X, Wu T, Guo H*. Essential Metals Zinc, Selenium, and Strontium Protect against Chromosome Damage Caused by Polycyclic Aromatic Hydrocarbons Exposure. Environ Sci Technol. 2016;50(2):951-60.

6.       Wang S, Bai Y, Deng Q, Chen Z, Dai J, Li X, Zhang W, Zhang X, He M, Wu T, Guo H*. Polycyclic aromatic hydrocarbons exposure and lung function decline among coke-oven workers: A four-year follow-up study. Environ Res. 2016;150:14-22.

7.       Wang T, Feng W, Kuang D, Deng Q, Zhang W, Wang S, He M, Zhang X, Wu T, Guo H*. The effects of heavy metals and their interactions with polycyclic aromatic hydrocarbons on the oxidative stress among coke-oven workers. Environ Res. 2015;140: 405-413.

8.      Kuang D, Zhang W, Deng Q, Zhang X, Huang K, Guan L, Hu D, Wu T, Guo H*. Dose-response relationships of polycyclic aromatic hydrocarbons exposure and oxidative damage to DNA and lipid in coke oven workers. Environ Sci Technol. 2013;47(13):7446-56.

9.       Guo H, Deng Q, Wu C, Hu L, Wei S, Xu P, Kuang D, Liu L, Hu Z, Miao X, Dr. Shen H, Lin D, Wu T. Variations in HSPA1B at 6p21.3 are associated with lung cancer risk and prognosis in Chinese populations. Cancer Res. 2011;71(24):7576-86.

10.   Guo H, Bai Y, Xu P, Hu Z, Liu L, Wang F, Jin G, Wang F, Deng Q, Tu Y, Feng M, Lu D, Shen H, Wu T. Functional promoter -1271G>C variant of HSPB1 predicts lung cancer risk and survival. J Clin Oncol. 2010;28(11):1928-35.