Professor of Environmental Medicine

Department of Environmental Medicine

* lubin@tjmu.edu.cn

Overview

Dr. Bin Lu is tenured Professor of Occupational and Environmental Health, the Dean of Institute of Environmental Medicine, School of Public Health, Huazhong University of Science & Technology (HUST). She graduated with a major in Maternal and Child Health Care in 1990 and received his PhD in Environmental Medicine in 2002 from Tongji Medical College. Dr. Lu’s research is mainly focused on health impact of environmental pollutants, environmental exposure and children development, and bactericides against antibiotic-resistant bacteria selectively. She has published over 70 original papers (30 of them published in SCI-collected journals with H index 17. Dr. Lu has been Principal Investigator (PI) of several NSFC project and other projects.

Academic Areas

Environmental medicine / Environmental chemistry

Research Interests

1.         Monitoring the exposure and helath impacts of trace environmental pollutants. Complex sample matrices in biological and environmental samples often affect the accurate monitoring of exposure and health impact of trace pollutants. Molecular imprinting is a generic method for preparation of tailor-made affinity materials with high molecular recognition selectivity. Molecularly imprinted polymers (MIPs) are synthetic cross-linked polymers formed by the presence of a target molecule (template). The template is then removed, which produces a cavity with molecular recognition sites that can bind selectivity to the original template. This bottom-up approach towards fabrication of nano cavities mimicking biological recognition materials (biomimetics) are videly used in bioseparation, sensing, catalysis, and controlled drug delivery systems. Research in my lab focuses on the application of MIPs to monitoring exposure levels of environmental pollutants, such as environmental endocrine disrupters, heavy metals, pesticides, myotoxins, bacteria and virus. Levels of xposure biomarkers, such as 8-hydroxydeoxyguanosine (8-OHdG), are also detected using MIP-based method to evaluate the health impact of trace environmental pollutants. Furthermore, in vivo and in vitro toxicity of nanoparticles, pharmaceuticals and personal care products (PPCPs), and mixture of different toxicants are studied. We also pay attention to the health impacts of water disinfection.

2.        Selective materials for theranostics and environment remediation. Nanomaterials that can selectively bind to the target biological marker in vivo are critical for theranostics. To introduce selective target binding, antibodies and antibody fragments can be utilized to coat nanoparticle probes. However, with these biological recognition materials, there are problems of high cost and in vivo degradation caused by proteases. It is therefore necessary to develop antibody substituents (artificial antibodies) that can be used for biomedical applications. My lab focuses on developing new functional materials for theranostics applications. Molecularly imprinted nanoparticles and composites will be designed, synthesized and tested for bioimaging and controlled delivery and release of therapeutic drugs. Presently, removal efficiencies for trace pollutants are limited due to the lack of selective pollution treatment methods. We are using the selective adsorption of MIPs to improve the selectivity and efficiency of trace pollutants removal.

Selected Professional Affiliations

Chinese Biomedical Engineering Society, Division of Transducers: Executive member

Chinese Society of Analytical Instrument, Division of Transducers: Executive member

Chinese Society for Preventative Medicine, member

Peer viewer for J Hazard Mater, Water Res, J Chromatogra A, J Chromatogra B, Anal Chim Acta, Process Biochem, Appl Surf Sci, Sci Total Environ, Anal Sci, J Neurol Sci, et al

Courses Taught

Courses for undergraduate students

Environment and health / Physical and chemical analysis: water quality / Physical and chemical analysis: air quality

Courses for graduated students

Labelling and analysis of biomolecules

Awards and Honors

2009     B Lu, L Zhu, J Zhang, H Tang, Y Shi, N Wang. Monitoring and controlling of trace environmental carcinogens. Excellent nature scientific research award of Chinese Ministry of Education

Education

1985/09-1990/06  

Bachelor's Degree of Medicine, Department of maternal and child health care, The Faculty of Preventive Medicine, Tongji Medical University

1996/09-1999/06  

Master's Degree of Medicine, Dept. of Environmental Health, Tongji Medical University

1999/09-2002/06  

Doctoral Degree of Medicine, Dept. of Environmental Health, Tongji Medical University, Huazhong University of Science and Technology

Professional/working Experience

1990, 7-1996,8

Physician, Yulin materal and child health care hospital, Yulin, Guangxi,

2002.07-present    

Professor, Institute of Environmental Medicine, Huazhong University of Science and Technology, Wuhan, Hubei

Past and ongoing projects, funding, programs

1.         Molecularly imprinted nanoparticles for theranostics (No. 21611130030). The National Natural Science Foundation of China.

2.        Detecting phosphoprotein biomarkers using a method based on molecularly recognized nano-materials (No. 21277054). The National Natural Science Foundation of China..

3.        Trace environmental hormones treatment system based on specific absorption and biodegraded membrane (No 30972435). The National Natural Science Foundation of China

4.        On-line trace estrogen detection system based on fluorescent nanoparticles (No. 20110142110021). Specialized Research Fund for the Doctoral Program of Higher Education.

5.        A new HIV diagnosis method based on multi-functional nano-materials (No 2014BCB049). Public welfare project of Hubei Province.

6.        Impacts of combined exposure of heavy metals and environmental estrogents on children neurodevelopment (No. WJ2015MA0260. Key projects of Hubei Provincial Commission for health and family planning.

7.        Impacts of Jingjiang waterway regulation project on water quality. Key project of Yangtze River Channel Bureau, Department of transportation (No 2015001)

Select Publications

Book chaper

Wan YC, Ma HT, Lu B*. MIPs in Aqueous Environments. Adv Biochem Eng Biotechnol. 2015, DOI 10.1007/10_2015_317

Textbook

Chief editor of ‘Health and quarantine’，National College Textbook, The national health and Family Planning Commission

Patents

1.         Bin Lu, Yating Wu, Lei Ye. Preparation and application of a fluorescent material。Chinese patents for invention NO. 201110039691.2

2.        Bin Lu, Qian Liu. A selective affinity biodegradation membrane. Chinese patents for invention NO. 201110395867.8

3.        Bin Lu, Zheng Huang, Jian Zhong, Meng Zhang, Yun Shi. A new method and kit for rapid detection of endotoxin. Chinese patents for invention NO. 201310075844.8

4.        Bin Lu, Xuejuan Wang, Yanjie Liu, Yun Shi. A method and kit for Acephate. Chinese patents for invention NO. Chinese patents for invention NO. 201410072679.5

5.        Bin Lu, Yating Wu, Hu Xia, Yun Shi, Yanjie Liu. Preparation and application of a dopamine derivative and molecularly imprinted polymer. Chinese patents for invention NO. 201410221419.X

6.        Bin Lu, Yanjie Liu, Fei Liu, Mifang Luo, Yun Shi. Preparation and application of an anti-virus nanomaterial. Chinese patents for invention NO. 201510387979.7

Journal Article

*Corresponding author

1.         C. Liu, J. Xu, J. Qi, Y. Liu, J. Kang, H. Wang, S. Chen, Z. Huang, B. Lu*. A Novel Nanobiocomposite Sandwich Immunosensor Based on molecularly imprinted nano-membrane for endotoxin detection. Sens. Actuator B-Chem.2019, 290:1-8

2.        C. Liu, H. Gong, W. Liu, B.Lu*, L. Ye*. Separation and Recycling of Functional Nanoparticles Using Reversible Boronate Ester and Boroxine Bonds. Ind. Eng. Chem. Res. 2019, 58, 4695−4703

3.        Y. Wan, Y. Liu, C. Liu, H. Ma, H. Yu, J. Kang, C. Gao, Z. Wu, D. Zheng*, B. Lu*. Rapid determination of neomycin in biological samples using fluorescent sensor based on quantum dots with doubly selective binding sites. J. Pharm. Biomed. Anal, 2018, 154:75-84

4.        H Ma, L Jiang, S Hajizadeh, H Gong, B Lu*, L Ye*. Nanoparticle-supported polymer brushes for temperature-regulated glycoprotein separation: investigation of structure–function relationship. J. Mater. Chem. B, 2018, 6, 3770-3781

5.        N. Li, F. Liu, Y. Liu, M. Luo, Y. Wan, Z. Huang, Q. Liao, F. Mei, Z. Wang, A. Jin, Y. Shi*, B. Lu*. Bio-inspired virus imprinted polymer for prevention of viral infections. Acta Biomater, 2017, 51: 175-183

6.        F. Liu, Q. Liu, Y. Zhang, Y. Liu, Y. Wan, K. Gao, Y. Huang, W. Xia, H. Wang, Y. Shi , Z. Huang*, B. Lu*. Molecularly imprinted nanofiber membranes enhanced biodegradation of trace bisphenol A by Pseudomonas aeruginosa. Chem Eng J, 2015, 262: 989-998

7.        Y. Wu, Y. Liu, X. Gao, K. Gao, H. Xia, M. Luo, X. Wang, L. Ye,, Y. Shi*, B Lu*. Monitoring bisphenol A and its biodegradation in water using a fluorescent molecularly imprinted chemosensor. Chemosphere, 2015,119: 515-523

8.       Y. Wu, Y. Zhang , M. Zhang, F. Liu, Y. Wan, Z. Huang, L. Ye, Q .Zhou, Y. Shi*, B Lu*. Selective and simultaneous determination of trace bisphenol A and tebuconazole in vegetable and juice samples by membrane-based molecularly imprinted solid-phase extraction and HPLC. Food Chem, 2014, 164: 527-535

9.        D Zheng, N Wang, X Wang, Y Tang, L Zhu, Z Huang*, H Tang, Y Shi, Y Wu, M Zhang, B Lu*. Effects of the interaction of TiO2 nanoparticles with bisphenol A on their physicochemical properties and in vitro toxicity. J. Hazard. Mater. 2012, 199-200:426-432

10.    Y Xie, H Li, L Wang, Q Liu, Y Shi , H Zheng, M Zhang, Y Wu, B Lu*. Molecularly imprinted polymer microspheres enhanced biodegradation of bisphenol A by acclimated activated sludge. Water Res, 2011, 45: 1189-1198