Associate Professor of Nutrition & Food Hygiene
Department of Nutrition & Food Hygiene
' 027-86550522
* tyh043@126.com
Academic Areas
Nutrition and Liver Damage, Aging, Diabetes.
Research Interests
> Liver damage mechanisms (exosomes, mitophagy, ferroptosis) and its preventing treatment.
> Molecule mechanism of diabetes and its preventive treatment.
> Probiotics treatment on inflammatory bowel disease in RCT.
> Senescence and its prevention with phytochemical.
Selected Professional Affiliations
> Secretary-General, Wuhan Nutrition Society
> Commissioner, Council of Community Nutrition and Health Management, China Nutrition Society
Courses Taught
Preventive Medicine (International student)/Experiment of Nutrition and Food Hygiene (Bachelor)/Preventive Medicine (Bachelor)/ Nutrition and Food Hygiene (Master)/ Nutrition and Beauty (Elective course).
Awards and Honors
> Plant flavonoids against alcoholic liver disease by inducing HO-1. Natural Science Prize: Second Prize. People's Government of Hubei Province. 2014.08. (3th)
Education
2008-2013 Ph.D., School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, China.
2003-2008 B.S, School of Public Health, Da Li University, China.
Professional/working Experience
2013-Present Assistant Professor, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, China.
Past and ongoing projects, funding, programs
> 2019-2022. The role of Rab7-mediated mitophagy and exosome in alcoholic liver iron overload and the protective effect of quercetin. NSFC. PI.
> 2015-2017. Study the Regulatory Mechanism of Quercetin on FOXO3-Frataxin Mediated Alcoholic Liver Mitochondrial Damage. NSFC. PI.
> 2018-2019. Frataxin deficiency in ethanol-inhibited mitiphagy by proteomics analysis. Hubei Natural and Science Foundation. PI.
> 2014-2015. Parkin and receptor mediated mitophagy in ALD and the propective effect of quercetin. China Post-Doc Foundation. PI.
> 2019-2020. The protective effect of Saccharomyces boulardii on Inflammatory bowel disease based on RCT. Anqi Nutrition Foundation. PI.
>
Select Publications
Books, patents
Yuhan Tang. Pollution in Food and Health. Chapter 2. Hubei Science and Technology Publisher. 2015.
Journal Article
First author and corresponding author:
1. Lin Xiao, Gang Luo, Yuhan Tang*, Ping Yao*, Quercetin and iron metabolism: What we know and what we need to know, Food and chemical toxicology, 2018, 114: 190-203.
2. Xinhong Zhu, Ting Xiong, Peiyi Liu, Xiaoping Guo, Lin Xiao, Feng Zhou, Yuhan Tang*, Ping Yao*, Quercetin ameliorates HFD-induced NAFLD by promoting hepatic VLDL assembly and lipophagy via the IRE1a/XBP1s pathway, Food and chemical toxicology, 2018.2.10, 114: 52-60.
3. Liu P, Lin H, Xu Y, Zhou F, Wang J, Liu J, Zhu X, Guo X, Tang Y*,YaoP*. Frataxin-Mediated PINK1-Parkin-Dependent Mitophagy in Hepatic Steatosis: The Protective Effects of Quercetin. Molecular Nutrition &Food Research, 2018, 62(16):e1800164.
4. Xiao L, Liu L, Guo X, Zhang S, Wang J, Zhou F, Liu L, Tang Y*, Yao P*. Quercetin attenuates high fat diet-induced atherosclerosis in apolipoprotein E knockout mice: A critical role of NADPH oxidase.Food Chem Toxicol. 2017 Jul;105:22-33. doi: 10.1016/j.fct.2017.03.048.
5. Tang Y#, Li J, Gao C, Xu Y, Li Y, Yu X, Wang J, Liu L, Yao P*.Hepatoprotective Effect of Quercetin on Endoplasmic Reticulum Stress and Inflammation after Intense Exercise in Mice through Phosphoinositide 3-Kinase and Nuclear Factor-Kappa B. Oxid Med Cell Longev. 2016;2016:8696587. doi: 10.1155/2016/8696587.
6. Yu X, Xu Y, Zhang S, Sun J, Liu P, Xiao L, Tang Y*, Liu L, Yao P*. Quercetin Attenuates Chronic Ethanol-Induced Hepatic Mitochondrial Damage through Enhanced Mitophagy. Nutrients. 2016 Jan 5;8(1). pii: E27. doi: 10.3390/nu8010027.
7. Li Y, Chen M, Xu Y, Yu X, Xiong T, Du M, Sun J, Liu L, Tang Y*, Yao P*. Iron-mediated Lysosomal Membrane Permeabilization in Ethanol Induced Hepatic Oxidative Damage and Apoptosis: Protective Effects of Quercetin. Oxidative Medicine and Cellular Longevity, 2016, doi.org/10.1155/2016/4147610.
8. Tang YH#, Li YY, Yu HY, Gao C, Liu L, Chen SD, Xing MY, Liu LG, Yao P*. Quercetin prevents ethanol-induced iron overload by regulating hepcidin through the BMP6/SMAD4 signaling pathway, J Nutr Biochem. 2014, 25(6):675-82.
9. Tang YH#, Li YY, Yu HY, Gao C, Liu L, Xing MY, Liu LG, Yao P*. Quercetin attenuates chronic ethanol hepatotoxicity: implication of “free” iron uptake and release. Food Chem Toxicol. 2014, 67:131-8.
10. Tang YH#, Gao C, Shi YR, Zhu LP, Hu XM, Wang D, Yang L, Yang XF, Liu LG, Yao P*. Quercetin attenuates ethanol-derived microsomal oxidative stress: Implication of haem oxygenase-1 induction, Food Chemistry, 132(4): 1769-1774, 2012.
11. Tang YH#, Xu J, Qu W, Peng XL, Xin P, Yang XF, Ying CJ, Sun XF, Hao LP*. Resveratrol reduces vascular cell senescence through attenuation of oxidative stress by SIRT1/NADPH oxidase -dependent mechanisms, J Nutr Biochem, 23(11): 1410-1416, 2012.
12. Tang YH#, Gao C#, Xing MY, Li YY, Zhu LP, Wang D, Yang XF, Liu LG, Yao P*. Quercetin prevents ethanol-induced dyslipidemia and mitochondrial oxidative stress, Food Chemical Toxicology, 50(5): 1194-1200, 2012.
13. Tang YH#, Tian H#, Shi YR, Gao C, Xing MY, Yang W, Bao W, Wang D, Liu LG, Yao P*. Quercetin suppressed CYP2E1-dependent ethanol hepatotoxicity via depleting heme pool and releasing CO, Phytomedicine, 20(8): 699-704, 2013.
