Li Liu

【Source: | Date:2019-06-04 】

Li Liuundefined

Associate professor of Epidemiology and Biostatistics

Department of Epidemiology and Biostatistics


* liul2012@hust.edu.cn

Academic Areas

Cancer Epidemiology / Molecular Epidemiology / Nutritional Epidemiology / Environmental Epidemiology / Clinical Epidemiology

Research Interests

Epidemiological studies to investigate the contribution of environmental factors (diet/lifestyle) and genetic susceptibility to the development of colorectal cancer

Clinical epidemiological study for the prognosis of gastrointestinal cancer

Meta-analysis in epidemiology

Courses Taught

Epidemiology / Clinical Epidemiology / Field Epidemiology / Principles and Methods of Epidemiology

Awards and Honors

2014     Hubei Provincial science and technological progression award

2014     Excellent scientific publication of Wuhan City

Education

2007-2012         Ph.D., Huazhong University of Science and Technology, Wuhan, China

2002-2007        B.S., Huazhong University of Science and Technology, Wuhan, China

Professional/working Experience

2015-present     Associate professor, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

2016-2018         Postdoctor, Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA

2016-2018         Postdoctor, Department of Nutrition, Harvard School of Public Health, Boston, USA

2012-2015         Lecturer, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Past and ongoing projects, funding, programs

2019-2020        Fecal microbiome in the early detection and prognostic prediction of colorectal cancer, Young talents program of Hubei provincial health and hygiene commission, PI

2014-2016         Genome-wide expression profiling-based copy number variations in the initiation and development of colorectal cancer, NSFC, PI

2014-2016         Genome-wide expression profiling-based copy number variations in the susceptibility of colorectal cancer, Doctoral Fund for The New Teacher of China Ministry of Education, PI


 

Select Publications

Journal Article

1.       Liu L, Nishihara R, Qian ZR, Tabung FK, Nevo D, Zhang X, Song M, Cao Y, Mima K, Masugi Y, Shi Y, da Silva A, Twombly T, Gu M, Li W, Hamada T, Kosumi K, Inamura K, Nowak JA, Drew DA, Lochhead P, Nosho K, Wu K, Wang M, Garrett WS, Chan AT, Fuchs CS, Giovannucci EL, Ogino S. Association Between Inflammatory Diet Pattern and Risk of Colorectal Carcinoma Subtypes Classified by Immune Responses to Tumor. Gastroenterology. 2017 Dec;153(6):1517-1530.e14.

2.        Yang W, Liu L, Masugi Y, Qian ZR, Nishihara R, Keum N, Wu K, Smith-Warner S, Ma Y, Nowak JA, Momen-Heravi F, Zhang L, Bowden M, Morikawa T, Silva AD, Wang M, Chan AT, Fuchs CS, Meyerhardt JA, Ng K, Giovannucci E, Ogino S, Zhang X. Calcium intake and risk of colorectal cancer according to expression status of calcium-sensing receptor (CASR). Gut. 2018 Aug;67(8):1475-1483. (co-first author)

3.        Liu L, Tabung FK, Zhang X, Nowak JA, Qian ZR, Hamada T, Nevo D, Bullman S, Mima K, Kosumi K, da Silva A, Song M, Cao Y, Twombly TS, Shi Y, Liu H, Gu M, Koh H, Li W, Du C, Chen Y, Li C, Li W, Mehta RS, Wu K, Wang M, Kostic AD, Giannakis M, Garrett WS, Hutthenhower C, Chan AT, Fuchs CS, Nishihara R, Ogino S, Giovannucci EL. Diets That Promote Colon Inflammation Associate With Risk of Colorectal Carcinomas That Contain Fusobacterium nucleatum. Clin Gastroenterol Hepatol. 2018 Oct;16(10):1622-1631.e3.

4.        Liu L, Nevo D, Nishihara R, Cao Y, Song M, Twombly TS, Chan AT, Giovannucci EL, VanderWeele TJ, Wang M, Ogino S.Utility of inverse probability weighting in molecular pathological epidemiology. Eur J Epidemiol. 2018 Apr;33(4):381-392.

5.        Yu X, Chen J, Li Y, Liu H, Hou C, Zeng Q, Cui Y, Zhao L, Li P, Zhou Z, Pang S, Tang S, Tian K, Zhao Q, Dong L, Xu C, Zhang X, Zhang S, Liu L, Wang A. Threshold effects of moderately excessive fluoride exposure on children's health: A potential association between dental fluorosis and loss of excellent intelligence. Environ Int. 2018 Sep;118:116-124. (Co-corresponding author)

6.        Hamada T, Liu L, Nowak JA, Mima K, Cao Y, Ng K, Twombly TS, Song M, Jung S, Dou R, Masugi Y, Kosumi K, Shi Y, da Silva A, Gu M, Li W, Keum N, Wu K, Nosho K, Inamura K, Meyerhardt JA, Nevo D, Wang M, Giannakis M, Chan AT, Giovannucci EL, Fuchs CS, Nishihara R, Zhang Z, Ogino S.  Vitamin D status after colorectal cancer diagnosis and patient survival according to immune response to tumour. Eur J Cancer. 2018 Sep 12;103:98-107. (co-first author)

7.        Kosumi K, Hamada T, Zhang S, Liu L, da Silva A, Koh H, Twombly TS, Mima K, Morikawa T, Song M, Nowak JA, Nishihara R, Saltz LB, Niedzwiecki D, Ou FS, Zemla T, Mayer RJ, Baba H, Ng K, Giannakis M, Zhang X, Wu K, Giovannucci EL, Chan AT, Fuchs CS, Meyerhardt JA, Ogino S. Prognostic association of PTGS2 (COX-2) over-expression according to BRAF mutation status in colorectal cancer: Results from two prospective cohorts and CALGB 89803 (Alliance) trial. Eur J Cancer. 2019 Apr;111:82-93. (co-first author)

8.       Li T, Wei S, Shi Y, Pang S, Qin Q, Yin J, Deng Y, Chen Q, Wei S, Nie S, Liu L. The dose-response effect of physical activity on cancer mortality: findings from 71 prospective cohort studies. Br J Sports Med. 2016 Mar;50(6):339-45.

9.        Liu L, Shi Y, Li T, Qin Q, Yin J, Pang S, Nie S, Wei S. Leisure time physical activity and cancer risk: evaluation of the WHO's recommendation based on 126 high-quality epidemiological studies. Br J Sports Med. 2016 Mar;50(6):372-8.

10.    Liu L, Wu J, Wu C, Zhong R, Zhang X, Tan W, Nie S, Miao X, Lin D. A functional polymorphism (-1607 1G2G) in the matrix metalloproteinase-1 promoter is associated with development and progression of lung cancer. Cancer. 2011 Nov 15;117(22):5172-81.

11.     Shi Y, Li T, Wang Y, Zhou L, Qin Q, Yin J, Wei S, Liu L, Nie S. Household physical activity and cancer risk: a systematic review and dose-response meta-analysis of epidemiological studies. Sci Rep. 2015 Oct 7;5:14901. (co-corresponding author)

12.    Yang W, Liu L, Keum N, Qian ZR, Nowak JA, Hamada T, Song M, Cao Y, Nosho K, Smith-Warner SA, Zhang S, Masugi Y, Ng K, Kosumi K, Ma Y, Garrett WS, Wang M, Nan H, Giannakis M, Meyerhardt JA, Chan AT, Fuchs CS, Nishihara R, Wu K, Giovannucci EL, Ogino S, Zhang X. Calcium Intake and Risk of Colorectal Cancer According to Tumor-infiltrating T Cells. Cancer Prev Res (Phila). 2019 Feb 13. doi: 10.1158/1940-6207.CAPR-18-0279. [Epub ahead of print]. (co-first author)

13.    Wang K, Yu X, Jiang H, Huang J, Wang H, Jiang H, Wei S, Liu L. Genome-wide expression profiling-based copy number variations and colorectal cancer risk in Chinese. 2019 Apr 18. doi: 10.1002/mc.23015. [Epub ahead of print]

14.    Liu L, Wu J, Zhong R, Wu C, Zou L, Yang B, Chen W, Zhu B, Duan S, Yu D, Tan W, Nie S, Lin D, Miao X. Multi-loci analysis reveals the importance of genetic variations in sensitivity of platinum-based chemotherapy in non-small-cell lung cancer. Mol Carcinog. 2013 Dec;52(12):923-31.

15.     Liu L, Yuan P, Liu L, Wu C, Zhang X, Guo H, Zhong R, Xu Y, Wu J, Duan S, Rui R, Wu T, Nie S, Miao X, Lin D. A functional -77T>C polymorphism in XRCC1 is associated with risk of breast cancer. Breast Cancer Res Treat. 2011 Jan;125(2):479-87.

16.    Chen D, Liu L, Xiao Y, Peng Y, Yang C, Wang Z. Ethnic-specific meta-analyses of association between the OPRM1 A118G polymorphism and alcohol dependence among Asians and Caucasians. Drug and Alcohol Dependence. 2012 Jun 1;123(1-3):1-6. (Co-first author)

17.     Keum N, Liu L, Hamada T, Qian ZR, Nowak JA, Cao Y, da Silva A, Kosumi K, Song M, Nevo D, Wang M, Chan AT, Meyerhardt JA, Fuchs CS, Wu K, Ogino S, Nishihara R, Zhang X. Calcium intake and colon cancer risk subtypes by tumor molecular characteristics. Cancer Causes Control. 2019 Apr 8. doi: 10.1007/s10552-019-01165-3. [Epub ahead of print] (co-first author)

18.    Pang S, Zhou Z, Yu X, Wei S, Chen Q, Nie S, Liang X, Liu L.The predictive value of integrated inflammation scores in the survival of patients with resected hepatocellular carcinoma: A Retrospective Cohort Study. Int J Surg. 2017 Jun;42:170-177.