Associate Professor of Occupational and Environmental Health
Department of Occupational and Environmental Health
Environmental Epidemiology / Environmental Toxicology
Dr. Zhang’s research activities focus on the toxic effects of xenobiotics and their underlying molecular mechanisms. He is currently conducting several studies on the effects of chemicals classified as endocrine disruptors on reproductive and neuronal health. Specific chemicals of interest include fluoride and persistent organic pollutants (i.e., brominated flame retardants).
Environmental Hygiene / Preventive Medicine
Awards and Honors
2018- Member, Youth committee of health toxicology branch of Chinese preventive medical association
2016- Member, Environmental health professional committee of Hubei preventive medical association
2009-2014 Ph.D., Huazhong University of Science and Technology, Wuhan, China
2004-2009 B.S., Huazhong University of Science and Technology, Wuhan, China
2017-present Associate Professor, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
2016-2017 Lecturer, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
2014-2016 Postdoc, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Past and ongoing projects, funding, programs
2016-2018 The role of imbalance of mitochondrial fusion/fission in PBDE-47-induced neurotoxicity, NSFC, PI
1. Modern environmental hygiene, 3rd edition, 2019;
2. Endemic fluorosis induced by coal-burning pollution, 2015.
1. Zhao Q, Niu Q, Chen J, Xia T, Zhou G, Li P, Dong L, Xu C, Tian Z, Luo C, Liu L, Zhang S,* Wang A.* Roles of mitochondrial fission inhibition in developmental fluoride neurotoxicity: mechanisms of action in vitro and associations with cognition in rats and children. Archives of Toxicology, 2019, 93(3): 709-726.
2. Zhou G, Yang L, Luo C, Liu H, Li P, Cui Y, Liu L, Yu X, Zeng Q, Chen J, Zhao Q, Dong L, Niu Q, Zhang S,* Wang A.* Low-to-moderate fluoride exposure, relative mitochondrial DNA levels, and dental fluorosis in Chinese children. Environment International, 2019, 127: 70-77.
3. Niu Q, Chen J, Xia T, Li P, Zhou G, Xu C, Zhao Q, Dong L, Zhang S,* Wang A.* Excessive ER stress and the resulting autophagic flux dysfunction contribute to fluoride-induced neurotoxicity. Environmental Pollution, 2018, 233: 889-899.
4. Yu X, Chen J, Li Y, Liu H, Hou C, Zeng Q, Cui Y, Zhao L, Li P, Zhou Z, Pang S, Tang S, Tian K, Zhao Q, Dong L, Xu C, Zhang X, Zhang S,* Liu L,* Wang A.* Threshold effects of moderately excessive fluoride exposure on children's health: A potential association between dental fluorosis and loss of excellent intelligence. Environment International, 2018, 118: 116-124.
5. Li P, Liu L, Zhou G, Tian Z, Luo C, Xia T, Chen J, Niu Q, Dong L, Zhao Q, Wang A,* Zhang S.* Perigestational exposure to low doses of PBDE-47 induces excessive ER stress, defective autophagy and the resultant apoptosis contributing to maternal thyroid toxicity. Science of the Total Environment, 2018, 645(15): 363-371.
6. Chen J, Niu Q, Xia T, Zhou G, Li P, Zhao Q, Xu C, Dong L, Zhang S,* Wang A.* ERK1/2-mediated disruption of BDNF–TrkB signaling causes synaptic impairment contributing to fluoride–induced developmental neurotoxicity. Toxicology, 2018, 410: 222-230.
7. Zhang S, Chen Y, Wu X, Gao H, Ma R, Jiang C, Kuang G, Zhao G, Xia T, Zhang X, Lei R, Zhang C, Li P, Xu C, Wang A.* The Pivotal Role of Ca2+ Homeostasis in PBDE-47-Induced Neuronal Apoptosis. Molecular Neurobiology, 2016, 53(10): 7078-7088.
8. Zhang S, Niu Q, Gao H, Ma R, Lei R, Zhang C, Xia T, Li P, Xu C, Wang C, Chen J, Dong L, Zhao Q, Wang A.* Excessive apoptosis and defective autophagy contribute to developmental testicular toxicity induced by fluoride. Environmental Pollution, 2016, 212: 97-104.
9. Zhang S, Zhang X, Liu H, Qu W, Guan Z, Zeng Q, Jiang C, Gao H, Zhang C, Lei R, Xia T, Wang Z, Yang L, Chen Y, Wu X, Cui Y, Yu L, Wang A.* Modifying Effect of COMT Gene Polymorphism and a Predictive Role for Proteomics Analysis in Children's Intelligence in Endemic Fluorosis Area in Tianjin, China. Toxicological Sciences, 2015, 144(2): 238-245.
10. Zhang S, Jiang C, Liu H, Guan Z, Zeng Q, Zhang C, Lei R, Xia T, Gao H, Yang L, Chen Y, Wu X, Zhang X, Cui Y, Yu L, Wang Z, Wang A.* Fluoride-elicited developmental testicular toxicity in rats: Roles of endoplasmic reticulum stress and inflammatory response. Toxicology and Applied Pharmacology, 2013, 271(2): 206-215.