Associate Professor of Environmental Medicine

Department of Environmental Medicine

* xiasheng@hust.edu.cn

Academic Areas

Environmental medicine, Stress response signaling in cancer

Research Interests

The implication of endoplasmic reticulum stress and unfolded protein response in cancer progression and its therapeutic potential.

The impact of maternal exposure to environmental pollutants on offspring neurodevelopment.

Courses Taught

Artificial Intelligence in Medical Frontiers

Awards and Honors

2015      Best paper award, Department of Biosciences, University of Oslo

2010     CONNEC, Erasmus Mundus Scholarship

Education

2013-2016        Ph.D., Department of Biosciences, University of Oslo, Norway

2009-2012       M.S., Beijing Forestry University, Beijing, China

2005-2009       B.S., Beijing Forestry University, Beijing, China

Professional/working Experience

2018-present   Associate Professor, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

2016-2018        Postdoc fellow, Department of Biosciences, University of Oslo, Norway

Past and ongoing projects, funding, programs

2018-2021        Talent Introduction Fund, Huazhong University of Science and Technology, PI.

2019-2021        Young Scientists Fund, National Science Foundation of China, PI.

Select Publications

Journal Article

*Corresponding author

1.        Wang Y, Wang K, Jin Y, Sheng X*. Endoplasmic reticulum proteostasis control and gastric cancer. Cancer Lett. 2019; 449: 263-271.

2.       Sheng X, Nenseth HZ, Qu S, Kuzu OF, Frahnow T, Simon L, Greene S, Zeng Q, Fazli L, Rennie PS, Mills IG, Danielsen H, Theis F, Patterson JB, Jin Y, Saatcioglu F. IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling. Nat Commun. 2019; 10(1): 323.

3.       Sheng X, Arnoldussen YJ, Storm ML, Tesikova M, Jin Y, Nenseth HZ, Zhao S, Mills IG, Fazli L, Rennie P, Risberg B, Wæhre H, Danielsen HE, Hotamisligil GS, Saatcioglu F. Divergent androgen regulation of unfolded protein response pathways drives prostate cancer. EMBO Mol Med. 2015; 7(6): 788-801.

4.       Storm M#, Sheng X#, Arnoldussen YJ, Saatcioglu F. Prostate cancer and the unfolded protein response. Oncotarget. 2016; 7: 54051-54066. (#co-first author)

5.       Sikkeland J#, Sheng X#, Jin Y, Saatcioglu F. STAMPing at the crossroads of normal physiology and disease states. Mol Cell Endocrinol. 2016; 425: 26-36. (#co-first author)

6.       Sheng X, Weng J, Zhang H, Li X, Zhang M, Xu M, Weng Q, Watanabe G, Taya K. Immunohistochemical localization of inhibin/activin subunits in the wild ground squirrel (Citellus dauricus Brandt) Ovary. J Reprod Dev. 2012; 58(5): 531-536.

7.       Sheng X, Zhang H, Zhang M, Zhang W, Hu X, Song M, Zhou J, Xu M, Weng Q, Watanabe G, Taya K. Seasonal changes in immunoreactivity of activin signaling component proteins in the wild ground squirrel testes. J Reprod Dev. 2012; 58(1): 126-131.

8.      Sheng X, Zhang H, Weng Q. Traditional Chinese medicine: China's bear farms prompt public outcry. Nature. 2012, 484: 455. (Correspondence paper)